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Ipamorelin Peptide: Benefits, Side Effects, and Clinical Usage

The Ipamorelin Peptide is gaining attention as a growth hormone secretagogue. In scientific research, it has shown promising potential in stimulating the production of growth hormones. This peptide may bring a myriad of potential benefits.

In this article, we’ll delve into the studies surrounding Ipamorelin. We’ll explore its mechanism of action, benefits, side effects, and pharmacokinetics.

And if you are interested in researching this drug, we’ve also got you covered. We’ll show you how NuScience Peptides provides high-quality Ipamorelin for research purposes.

So let’s get started.

Part 1. Ipamorelin Peptide: Its Background and Mechanism of Action

Ipamorelin is a pentapeptide peptide that is derived from GHRP-1. It stands out due to its selective growth hormone (GH) release properties without significantly altering other hormone levels.

Below, we have discussed its defining characteristics and how it operates:

  • Substance: Ipamorelin is specifically designed to stimulate the release of GH.
  • Synonyms: Also recognized as NNC 26-0161.
  • Molecular Formula: Structurally represented as C38H49N9O5.
  • MW: A molecular weight of 711.9 g/mol.
  • Manufacturer: Initially developed by Novo Nordisk in Denmark, also produced by Helsinn Therapeutics.
  • Route: Administered via IV, SC, and IN routes.

Chemical structures of different GHSs, including Ipamorelin

Ipamorelin increases plasma GH levels without affecting prolactin, FSH, LH, TSH, ACTH, or cortisol levels. This unique attribute makes it an exciting area of study. (Ishida et al., 2020)

You can legally request Ipamorelin peptide from NuScience Peptides here.

Now let’s look at the pharmacologic properties of this peptide proven by a study.

Part 2. A Pharmacologic Study of Ipamorelin Peptide

A comprehensive study has checked the Pharmacological profile of Ipamorelin. This study assessed its pharmacokinetics (PK) and pharmacodynamics (PD). A broad range of doses were administered to healthy volunteers. And this activity offered noteworthy insights into how this compound behaves in the human body.

Key findings of the study include:

  • The PK parameters of Ipamorelin exhibited dose-proportionality. It signifies the predictable nature of its effects at various dosages.
  • A short terminal half-life of 2 hours was identified. It indicates rapid processing within the body.
  • Clearance was determined to be 0.078 L/h/kg. And the volume of distribution at steady-state was 0.22 L/kg.
  • Ipamorelin’s time course of GH stimulation resulted in a single burst of GH release. The peak appeared at 0.67 hours. And it was followed by a rapid decline to negligible GH concentrations.
  • Population fitting and an indirect response model revealed a SC50 of 214 nmol/L. It’s the concentration required for half-maximal GH stimulation.
  • The maximal GH production rate was 694 mlU/L/h.
  • The inter-individual variability of PD parameters was larger than that of PK parameters.

The comprehensive modeling provides valuable insights into the peptide’s function. (Gobburu et al. 1999)

Now that you have the know-how let’s move on to the Ipamorelin benefits and clinical uses.

Part 3. Studies Showing Ipamorelin Benefits & Clinical Uses

Delving deep into scientific research is critical to understand any drug’s benefits & potential applications. Several studies have been conducted on Ipamorelin. They demonstrate the potential of Ipamorelin peptides in various medical fields.

Let’s look at three main areas where Ipamorelin has shown significant promise.

1.   Ipamorelin and Bone Mineral Content in Rats

A study was performed to see the effects of Ipamorelin on bone mineral content (BMC). The research yielded noteworthy results. These results indicate how Ipamorelin and GHRP-6, another GHS, enhanced BMC by elevating bone volume. And it’s all done without altering the volumetric bone mineral density (BMD).

Let’s look at the results!

Key findings

  • A significant increase in cortical BMC. The rise in the cross-sectional bone area drove it.
  • Expanded volumes of both femur and vertebra L6. While consistent volumetric BMDs were maintained.
  • Body weight, cortical bone area, and BMC were boosted with Ipamorelin and GHRP-6 treatments.
  • After 12 weeks, a notable escalation in dry defatted weight and bone volume was seen. It was seen in Femur and Vertebra L6.

Percent change in BMD with Ipamorelin (IPA) during 12 Weeks of rat treatment

So, Ipamorelin and other GHSs could promote bone growth without affecting volumetric BMD. This finding suggests possible therapeutic use for bone volume deficiencies. (Svensson et al. 2000)

You can legally request Ipamorelin peptide at NuScience Peptides here.

2.   Ipamorelin Stimulates Longitudinal Bone Growth in Rats

Ipamorelin exhibits distinct growth hormone (GH)-releasing properties. A research study significantly influenced longitudinal bone growth rate (LGR) and body weight (BW).

Here are the results;

Key findings

  • Ipamorelin dose-dependently amplified LGR and boosted BW gain. It was done without impacting total IGF-I levels, IGFBPs, or serum bone markers.
  • Tartrate-resistant acid phosphatase-positive multinuclear cells in the tibia metaphysis remained unchanged.
  • The pituitary response to ipamorelin slightly reduced plasma GH response. Yet pituitary GH content stayed consistent.

But still, future clinical studies are required to explore Ipamorelin’s potential in treating growth retardation in children. (Johanson et al. 1999)

3.   Ipamorelin for Postoperative Ileus Management

Postoperative ileus is a clinical challenge after abdominal surgery. Ipamorelin was also examined for its potential role in managing this challenge. The Phase 2, double-blind, randomized study evaluated its safety and efficacy.

Let’s check the results;

Key findings

  • The study involved 117 patients with similar demographic and disease characteristics.
  • The overall occurrence of treatment-emergent adverse events was 87.5% in the ipamorelin group. And it was 94.8% in the placebo group.
  • The median time to the first tolerated meal was notably shorter in the ipamorelin group (25.3 hours) than in the placebo group (32.6 hours). But the difference wasn’t statistically significant.
  • Ipamorelin was well tolerated, with no significant differences in key and secondary efficacy analyses. (Beck et al. 2014)

You can legally buy Ipamorelin peptide at NuScience Peptides here.

But keep in mind that no drug is completely devoid of side effects. Let’s see some of the possible Ipamorelin side effects.

Part 4. Possible Ipamorelin Side Effects

While research into Ipamorelin is still relatively limited, potential side effects may arise due to its nature as a growth hormone secretagogue.

Given its mechanism of action, possible side effects could include;

  • Fluid retention
  • Joint pain
  • Headaches
  • Increased hunger.

Some users might also experience a heightened response to insulin. And this will impact blood sugar levels.

However, it is vital to note that these side effects are largely speculative. And more extensive research is needed to establish the side effect profile of Ipamorelin definitively. The under-explored status of this compound underscores the urgent need for further investigations into its long-term safety and potential risks.

So if you are interested in Ipamorelin side effects research, you can request the peptide from NuScience Peptide.

Part 5. Request Ipamorelin Peptide online: NuScience Peptides

NuScience Peptides is a reputable provider of high-purity peptides. And it’s perfect for your scientific research needs.

They stand out for their competitive pricing and the high trust they’ve earned in the market. Here are some of the unique facilities of NuScience Peptides.

  • High Purity

NuScience places great importance on the purity of its products. Every peptide, including Ipamorelin, undergoes rigorous lab testing. And they are certified for the highest possible purity.

  • Same Day Shipping

Orders placed before 12:00 pm EST for in-stock items are shipped on the same day. This will ensure that your research progresses without delay.

  • Dedicated Service

The NuScience team is always ready to assist with your customer service requests. It will prioritize your satisfaction and a smooth shopping experience.

  • Free Shipping

To enhance your buying experience, NuScience offers free shipping on all orders totaling $125 or more.

Ipamorelin from NuScience Peptide

So, whether you’re initiating a new study or continuing an existing one, NuScience Peptides is your reliable source. Visit their online store now to request Ipamorelin and experience the quality and service that sets them apart.

Remember, all products sold are strictly for research, not for human consumption.

Conclusion

Ipamorelin is a growth hormone secretagogue. It has selective and potential benefits in bone growth and postoperative ileus management. While some potential side effects have been suggested, further comprehensive research is needed to understand its safety and efficacy fully.

For scientists interested in researching Ipamorelin, NuScience Peptides is an ideal source. It offers high-purity peptides backed by rigorous lab testing. Visit NuScience Peptides today and explore the potential of Ipamorelin for your next research project.

References

Beck, D. E., Sweeney, W. B., & McCarter, M. D. (2014). Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. International Journal of Colorectal Disease, 29(12), 1527–1534. https://doi.org/10.1007/s00384-014-2030-8

Gobburu, J. V. S., Agersø, H., Jusko, W. J., & Ynddal, L. (1999). Pharmacokinetic-Pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharmaceutical Research, 16(9), 1412–1416. https://doi.org/10.1023/A:1018955126402

Ishida, J., Saitoh, M., Ebner, N., Springer, J., Anker, S. D., & von Haehling, S. (2020). Growth hormone secretagogues: History, mechanism of action, and clinical development. JCSM Rapid Communications, 3(1), 25–37. https://doi.org/10.1002/rco2.9

Johanson, P. B., Nowak, J., & Skjærbæk, C. (1999). Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Hormone & IGF Research, 9(2), 106–113. https://doi.org/10.1054/ghir.1999.9998

Svensson, J., Lall, S., Dickson, S., Bengtsson, B., Romer, J., Ahnfelt-Ronne, I., Ohlsson, C., & Jansson, J. (2000). The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. Journal of Endocrinology, 165(3), 569–577. https://doi.org/10.1677/joe.0.1650569

FDA DISCLAIMER

Statements made in this article are not evaluated by the FDA (US Food & Drug Association.) These products are not intended to diagnose, treat, or prevent disease. This Ipamorelin Peptide is for research purposes only. It is suitable for in vitro tests and lab experiments. Human or animal usage is strictly prohibited. Handle only by certified professionals. It is not a drug, food, or cosmetic. And should not be misbranded or misused as such.