Tirzepatide weight loss therapy stands in the pursuit of effective weight management. This treatment has gained significant attention within the scientific community.
Researchers are eager to understand how it works and explore its potential benefits for weight loss.
This article will discuss Tirzepatide weight loss therapy, its benefits, and its side effects. Furthermore, we will provide information on where to purchase this peptide online.
So let’s get started with the overview of this new drug.
Part 1. The Dual GIP and GLP-1 Receptor Agonist: Tirzepatide
Tirzepatide is a 39 amino acid synthetic peptide with dual agonist activity at GIP and GLP-1 receptors. It targets impaired insulin production and action in type 2 diabetes.
But keep in mind that Tirzepatide is only FDA-approved for treating type 2 diabetes mellitus. It is not approved for treating type-1 diabetes mellitus.
It can be used off-label for treating obesity. Tirzepatide is currently implemented as a second-line diabetes medication. Tirzepatide exhibited superior effects compared to the selective GLP-1 receptor agonist dulaglutide. (Thomas et al., 2020) (Farzam et al., 2023)
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This was all about Tirzepatide. Now move toward the main Weight loss theory.
Part 2. Tirzepatide Weight Loss Therapy: A Systematic Review
Obesity is a metabolic disease that is related to a variety of diseases, along with affecting the quality of life. Currently, a large number of drugs are used for weight loss.
A study was performed to gauge the effectiveness of Tirzepatide weight loss theory in some patients. Here are the results;
- Multiple doses of Tirzepatide(5 mg, 10 mg, and 15 mg) were effective in promoting weight loss.
- Tirzepatide peptide led to significant weight reduction along with improvements in HbA1c levels.
- Mild gastrointestinal events, such as diarrhea, nausea, vomiting, and decreased appetite, were common.
- Tirzepatide showed a favorable safety profile with no serious adverse events compared to placebo.
However, caution is advised regarding its potential gastrointestinal reactions.
Further research is necessary to gain more comprehensive insights into tirzepatide’s effectiveness. (Lin et al., 2023)
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Moving forward from the systematic review. Let’s explore the Tirzepatide benefits in T2DM with various studies.
Part 3. Promising Benefits of Tirzepatide
Many studies were performed for the evaluation of Tirzepatide weight loss therapy in type 2 diabetes. And the results were quite promising! Most important are the reduction in HbA1c levels and favorable safety profiles.
Let’s get in deep touch with its benefits one by one.
Improving Beta-cell Function and Insulin Sensitivity with Tirzepatide
Tirzepatide exhibits improvements in beta-cell function and insulin sensitivity.
The treatment results in;
- Significant increases in HOMA2-B indices, indicating enhanced beta-cell function.
- Tirzepatide peptide led to reductions in intact proinsulin levels and proinsulin/insulin ratio.
- The drug effectively lowered glucose-adjusted glucagon levels.
- Regarding insulin sensitivity, Tirzepatide demonstrated decreases in HOMA2-IR indices and fasting insulin levels.
- Tirzepatide treatment resulted in increased adiponectin levels.
- And also in elevated levels of IGF-binding proteins IGFBP-1 and IGFBP-2.
- The insulin-sensitizing effects of Tirzepatide were not solely attributed to weight loss.
Tirzepatide shows promise in enhancing beta-cell function and improving insulin sensitivity. (Thomas et al., 2020)
Managing Type 2 Diabetes with Tirzepatide
Tirzepatide effectively reduces HbA1c levels in individuals with type 2 diabetes.
- It leads to significant dose-dependent weight loss
- Also leads to outperforming GLP-1 RAs like semaglutide and dulaglutide.
- It leads to higher discontinuation rates, especially with the 15 mg dose.
- No evidence suggests a higher incidence of serious adverse events or all-cause mortality.
- This analysis provides valuable guidance to clinicians on tirzepatide use for managing type 2 diabetes.
- It offers superior glycemic control and weight reduction compared to basal insulin and once-weekly GLP-1 RAs.
However, the occurrence of gastrointestinal adverse events should be taken into account. Future research is required to explore Tirzepatide’s long-term benefits compared to other medications. (Karagiannis et al. 2022)
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The SURPASS Clinical Trials: Role of Tirzepatidein Diabetes Management
The SURPASS clinical trial program evaluated the Tirzepatide effects in managing type 2 diabetes (T2DM). The program consisted of several phase 3 clinical trials conducted globally.
These trials involved treatment-naïve patients and those on insulin. Comparators included GLP-1 receptor agonists, insulin analogs, and short-acting insulin. The trials assessed once-weekly Tirzepatide doses of 5 mg, 10 mg, and 15 mg.
The result shown is;
- The primary endpoint was the change in levels of HbA1c.
- Additionally, the SURPASS-CVOT trial focused on cardiovascular outcomes in patients with T2DM.
- The results of these trials will provide valuable insights into the efficacy and safety of Tirzepatide in T2DM management. (Min et al., 2020)
Now, let’s shift our focus to the possible Tirzepatide side effects.
Part 4. The Possible Tirzepatide Side Effects
Most users do not experience significant adverse drug reactions. The primary effects reported are gastrointestinal, but other side effects have also been reported.
Below are the adverse drug reactions reported by System Organ Class.
- Gastrointestinal include decreased appetite, nausea, diarrhea, vomiting, acid reflux, and constipation.
- Sinus tachycardia has been reported in some cases.
- Infrequent cases of acute kidney injury have also been observed.
- Hypersensitivity reactions at the injection site have been infrequently reported.
- Tirzepatide carries a risk of pancreatitis.
- Cholelithiasis, cholecystitis, and transient worsening of preexisting diabetic retinopathy symptoms have also been reported.
- There is a small risk of hypoglycemia, particularly in patients on insulin or sulfonylureas.
- Prompt discussion with a physician is advised for symptoms or vision changes. (Farzam et al., 2023)
Lastly, let’s take a moment to discuss Tirzepatide’s cost and the online platforms that offer a convenient buying experience.
Part 5. Tirzepatide Cost: Where to Buy Online?
If you want to buy Tirzepatideonline for research purposes, NuScience Peptides is your go-to shop.
We provide a seamless experience with our top-notch services and high-quality products. While on the topic of Terzepatide cost, we offer this peptide at different prices. You can buy it from us for $89.99 – $775.00.
Why Buy from NuScience Peptides?
- We offer same-day shipping on all orders of in-stock items placed before 12:00 pm EST. This means you can enjoy the convenience of receiving your order swiftly.
- Our team is always ready to assist you with any customer service requests you may have.
- Your satisfaction is our priority. And we always strive to provide excellent service.
- We offer free shipping on all the orders totaling $125 or more. No need to worry about additional shipping costs
- Every product that we offer undergoes lab testing to ensure the best purity.
- You can trust that our Tirzepatide is of the highest possible quality.
Choose NuScience Peptides for a reliable and hassle-free experience when buying Tirzepatide online for research purposes.
Tirzepatide Peptide from NuScience Peptides
Conclusion
Tirzepatide works as a weight-loss therapy for individuals with type 2 diabetes. It exhibits efficacy in reducing HbA1c levels.
Tirzepatide has a favorable safety profile with no evidence of increased severe adverse events. Researchers have also observed improvements in beta-cell function and insulin sensitivity with Tirzepatide treatment.
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References
Farzam, K., & Patel, P. (2023, May 26). Tirzepatide. NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK585056/
Karagiannis, T., Avgerinos, I., Liakos, A., Prato, S. D., Matthews, D. R., Tsapas, A., & Bekiari, E. (2022). Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: A systematic review and meta-analysis. Diabetologia, 65(8), 1251–1261. https://doi.org/10.1007/s00125-022-05715-4
Lin, F., Yu, B., Ling, B., Lv, G., Shang, H., Zhao, X., Jie, X., Chen, J., & Li, Y. (2023). Weight loss efficiency and safety of tirzepatide: A Systematic review. PLOS ONE, 18(5). https://doi.org/10.1371/journal.pone.0285197
Min, T., & Bain, S. C. (2020). The role of tirzepatide, dual GIP and GLP-1 receptor agonist, in the management of type 2 diabetes: The SURPASS clinical trials. Diabetes Therapy, 12(1), 143–157. https://doi.org/10.1007/s13300-020-00981-0
Thomas, Nikooienejad, Bray, Cui, Wilson, Duffin, Milicevic, Haupt, & Robins. (2020). Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism, 106(2), 388–396. https://doi.org/10.1210/clinem/dgaa863
DISCLAIMER
The information provided in this article is for informational and educational purposes only. Consult with a healthcare professional regarding any concerns about Tirzepatide. The United States Food and Drug Administration (FDA) has not evaluated the statements made in this article for this drug. Purchase of Tirzepatide online should be used for research purposes only and following applicable laws and regulations.